Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity.

• Главные авторы: Maikel Izquierdo (Автор), De Lin (Автор), Sandra O'Neill (Автор), Lauren A Webster (Автор), Christy Paterson (Автор), John Thomas (Автор), Mirtha Elisa Aguado (Автор), Enrique Colina Araújo (Автор), Daniel Alpízar-Pedraza (Автор), Halimatu Joji (Автор), Lorna MacLean (Автор), Anthony Hope (Автор), David W Gray (Автор), Martin Zoltner (Автор), Mark C Field (Автор), Jorge González-Bacerio (Автор), Manu De Rycker (Автор)
• Формат: ‌
• Опубликовано: Public Library of Science (PLoS), 2024-02-01T00:00:00Z.
• Предметы: article
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<h4>Background</h4>Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and leads to ~10,000 deaths each year. Nifurtimox and benznidazole are the only two drugs available but have significant adverse effects and limited efficacy. New chemotherapeutic agents are urgently...