Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity.

• Main Authors: Maikel Izquierdo (Author), De Lin (Author), Sandra O'Neill (Author), Lauren A Webster (Author), Christy Paterson (Author), John Thomas (Author), Mirtha Elisa Aguado (Author), Enrique Colina Araújo (Author), Daniel Alpízar-Pedraza (Author), Halimatu Joji (Author), Lorna MacLean (Author), Anthony Hope (Author), David W Gray (Author), Martin Zoltner (Author), Mark C Field (Author), Jorge González-Bacerio (Author), Manu De Rycker (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and leads to ~10,000 deaths each year. Nifurtimox and benznidazole are the only two drugs available but have significant adverse effects and limited efficacy. New chemotherapeutic agents are urgently...