Late-stage cascade of oxidation reactions during the biosynthesis of oxalicine B in Penicillium oxalicum

• Main Authors: Tao Zhang (Author), Guowei Gu (Author), Guodong Liu (Author), Jinhua Su (Author), Zhilai Zhan (Author), Jianyuan Zhao (Author), Jinxiu Qian (Author), Guowei Cai (Author), Shan Cen (Author), Dewu Zhang (Author), Liyan Yu (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxalicine B (1) is an α-pyrone meroterpenoid with a unique bispirocyclic ring system derived from Penicillium oxalicum. The biosynthetic pathway of 15-deoxyoxalicine B (4) was preliminarily reported in Penicillium canescens, however, the genetic base and biochemical characterization of tailoring rea...