In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis

• Main Authors: Hamza Ali Khan (Author), Muhammad Umair Asif (Author), Muhammad Khurram Ijaz (Author), Metab Alharbi (Author), Yasir Ali (Author), Faisal Ahmad (Author), Ramsha Azhar (Author), Sajjad Ahmad (Author), Muhammad Irfan (Author), Maryana Javed (Author), Noorulain Naseer (Author), Abdul Aziz (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypotrichosis is an uncommon type of alopecia (hair loss) characterized by coarse scalp hair caused by the reduced or fully terminated activity of the Lipase-H (LIPH) enzyme. LIPH gene mutations contribute to the development of irregular or non-functional proteins. Because several cellular processes...