Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci

• Main Authors: Chani J. Hodonsky (Author), Adam W. Turner (Author), Mohammad Daud Khan (Author), Nelson B. Barrientos (Author), Ruben Methorst (Author), Lijiang Ma (Author), Nicolas G. Lopez (Author), Jose Verdezoto Mosquera (Author), Gaëlle Auguste (Author), Emily Farber (Author), Wei Feng Ma (Author), Doris Wong (Author), Suna Onengut-Gumuscu (Author), Maryam Kavousi (Author), Patricia A. Peyser (Author), Sander W. van der Laan (Author), Nicholas J. Leeper (Author), Jason C. Kovacic (Author), Johan L.M. Björkegren (Author), Clint L. Miller (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Genome-wide association studies (GWASs) have identified hundreds of risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWASs, and the causal gene-regulatory mechanisms of these risk loci during atherosclerosis remain unclear. We incorporat...