Xiaoyaosan ameliorates depressive-like behavior and susceptibility to glucose intolerance in rat: involvement of LepR-STAT3/PI3K pathway in hypothalamic arcuate nucleus

• Main Authors: Wenqi Qiu (Author), Qian Wu (Author), Kaiwen Zhang (Author), Xiaoli Da (Author), Kairui Tang (Author), Naijun Yuan (Author), Lijuan Deng (Author), Mansi Wu (Author), Ying Zhang (Author), Jiangyan Quan (Author), Qingyu Ma (Author), Xiaojuan Li (Author), Jiaxu Chen (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Accumulating evidence has demonstrated that arcuate nucleus (ARC) of the hypothalamus is likely responsible for the close association between chronic stress, depression, and diabetes. Xiaoyaosan (XYS), a Chinese herbal formula, remarkably improves depressive-like behavior and glu...