From regulation to deregulation of p53 in hematologic malignancies: implications for diagnosis, prognosis and therapy

• Main Authors: Seyed Esmaeil Ahmadi (Author), Elahe Rahimian (Author), Samira Rahimi (Author), Bahman Zarandi (Author), Mehran Bahraini (Author), Maral Soleymani (Author), Seyed Mehrab Safdari (Author), Ashkan Shabannezhad (Author), Niloofar Jaafari (Author), Majid Safa (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The p53 protein, encoded by the TP53 gene, serves as a critical tumor suppressor, playing a vital role in maintaining genomic stability and regulating cellular responses to stress. Dysregulation of p53 is frequently observed in hematological malignancies, significantly impacting disease pro...