Retrospective Assessment of Translational Pharmacokinetic-Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor

• المؤلفون الرئيسيون: Anita Moein (مؤلف), Jin Y. Jin (مؤلف), Matthew R. Wright (مؤلف), Bruno Alicke (مؤلف), Harvey Wong (مؤلف)
• التنسيق: كتاب
• منشور في: Adis, Springer Healthcare, 2024-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background and Objectives Despite significant progress in biomedical research, the rate of success in oncology drug development remains inferior to that of other therapeutic fields. Mechanistic models provide comprehensive understanding of the therapeutic effects of drugs, which is crucial...