Metagenomic next generation sequencing of plasma RNA for diagnosis of unexplained, acute febrile illness in Uganda.

• Main Authors: Abraham J Kandathil (Author), Paul W Blair (Author), Jennifer Lu (Author), Raghavendran Anantharam (Author), Kenneth Kobba (Author), Matthew L Robinson (Author), Sultanah Alharthi (Author), Edgar C Ndawula (Author), J Stephen Dumler (Author), Francis Kakooza (Author), Mohammed Lamorde (Author), David L Thomas (Author), Steven L Salzberg (Author), Yukari C Manabe (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metagenomic next generation metagenomic sequencing (mNGS) has proven to be a useful tool in the diagnosis and identification of novel human pathogens and pathogens not identified on routine clinical microbiologic tests. In this study, we applied mNGS to characterize plasma RNA isolated from 42 study...