Impact of drug loading in mesoporous silica-amorphous formulations on the physical stability of drugs with high recrystallization tendency

• Main Authors: Rayane S.C.M.Q. Antonino (Author), Michael Ruggiero (Author), Zihui Song (Author), Thais Leite Nascimento (Author), Eliana Martins Lima (Author), Adam Bohr (Author), Matthias Manne Knopp (Author), Korbinian Löbmann (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, a method is described to determine the monolayer loading capacity (MLC) of the drugs naproxen and ibuprofen, both having high recrystallization tendencies, in mesoporous silica (MS), a well known carrier that is able to stabilize the amorphous form of a drug. The stabilization has bee...