Tumor growth and overall survival modeling to support decision making in phase Ib/II trials: A comparison of the joint and two‐stage approaches

Abstract Model‐based tumor growth inhibition (TGI) metrics are increasingly used to predict overall survival (OS) data in Phase III immunotherapy clinical trials. However, there is still a lack of understanding regarding the differences between two‐stage or joint modeling methods to leverage Phase I...

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Bibliographic Details
Main Authors: Mathilde Marchand (Author), Antonio Gonçalves (Author), François Mercier (Author), Pascal Chanu (Author), Jin Y. Jin (Author), Jérémie Guedj (Author), René Bruno (Author)
Format: Book
Published: Wiley, 2024-06-01T00:00:00Z.
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