Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells

• Những tác giả chính: Nobuhiko Sugito (Tác giả), Kazuki Heishima (Tác giả), Yukihiro Akao (Tác giả)
• Định dạng: Sách
• Được phát hành: Elsevier, 2022-12-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Kirsten rat sarcoma virus (KRAS) mutations are frequently detected in many cancers and are major driver genes. Therefore, KRAS inhibitors have been the subject of extensive research. We developed chemically modified MIR143-3p (MIR143#12), which exhibits higher anticancer activity and nuclease resist...