Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores

Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores

DNA gyrase is an important target for the development of novel antibiotics. Although ATP-competitive DNA gyrase (GyrB) inhibitors are a well-studied class of antibacterial agents, there is currently no representative used in therapy, largely due to unwanted off-target activities. Selectivity of GyrB...

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Main Authors: Tihomir Tomašič (Author), Asta Zubrienė (Author), Žiga Skok (Author), Riccardo Martini (Author), Stane Pajk (Author), Izidor Sosič (Author), Janez Ilaš (Author), Daumantas Matulis (Author), Sharon D. Bryant (Author)
Format: Book
Published: MDPI AG, 2021-08-01T00:00:00Z.
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3rd Floor Main Library

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