Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores

• Główni autorzy: Tihomir Tomašič (Autor), Asta Zubrienė (Autor), Žiga Skok (Autor), Riccardo Martini (Autor), Stane Pajk (Autor), Izidor Sosič (Autor), Janez Ilaš (Autor), Daumantas Matulis (Autor), Sharon D. Bryant (Autor)
• Format: Książka
• Wydane: MDPI AG, 2021-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

DNA gyrase is an important target for the development of novel antibiotics. Although ATP-competitive DNA gyrase (GyrB) inhibitors are a well-studied class of antibacterial agents, there is currently no representative used in therapy, largely due to unwanted off-target activities. Selectivity of GyrB...