Low frequency of mismatch repair deficiency in gallbladder cancer

• Main Authors: Benjamin Goeppert (Author), Stephanie Roessler (Author), Marcus Renner (Author), Moritz Loeffler (Author), Stephan Singer (Author), Melina Rausch (Author), Thomas Albrecht (Author), Arianeb Mehrabi (Author), Monika Nadja Vogel (Author), Anita Pathil (Author), Elena Czink (Author), Bruno Köhler (Author), Christoph Springfeld (Author), Christian Rupp (Author), Karl Heinz Weiss (Author), Peter Schirmacher (Author), Magnus von Knebel Doeberitz (Author), Matthias Kloor (Author)
• Format: Book
• Published: BMC, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background DNA mismatch repair (MMR) deficiency is a major pathway of genomic instability in cancer. It leads to the accumulation of numerous mutations predominantly at microsatellite sequences, a phenotype known as microsatellite instability (MSI). MSI tumors have a distinct clinical behav...