Engineering the microenvironment of P450s to enhance the production of diterpenoids in Saccharomyces cerevisiae

• Main Authors: Yatian Cheng (Author), Linglong Luo (Author), Hao Tang (Author), Jian Wang (Author), Li Ren (Author), Guanghong Cui (Author), Yujun Zhao (Author), Jinfu Tang (Author), Ping Su (Author), Yanan Wang (Author), Yating Hu (Author), Ying Ma (Author), Juan Guo (Author), Luqi Huang (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytochrome P450 enzymes play a crucial role as catalysts in the biosynthesis of numerous plant natural products (PNPs). Enhancing the catalytic activity of P450s in host microorganisms is essential for the efficient production of PNPs through synthetic biology. In this study, we engineered Saccharom...