Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease

• Main Authors: Barbara Calamini (Author), Nathalie Geyer (Author), Nathalie Huss-Braun (Author), Annie Bernhardt (Author), Véronique Harsany (Author), Pierrick Rival (Author), May Cindhuchao (Author), Dietmar Hoffmann (Author), Sabine Gratzer (Author)
• Format: Book
• Published: The Company of Biologists, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is a fatal neurodegenerative disorder that is primarily caused by the degeneration and loss of dopaminergic neurons of the substantia nigra in the ventral midbrain. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of late-onset PD iden...