Hypochlorite-Modified LDL Induces Arrhythmia and Contractile Dysfunction in Cardiomyocytes

• Main Authors: Chintan N. Koyani (Author), Susanne Scheruebel (Author), Ge Jin (Author), Ewald Kolesnik (Author), Klaus Zorn-Pauly (Author), Heinrich Mächler (Author), Gerald Hoefler (Author), Dirk von Lewinski (Author), Frank R. Heinzel (Author), Brigitte Pelzmann (Author), Ernst Malle (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neutrophil-derived myeloperoxidase (MPO) and its potent oxidant, hypochlorous acid (HOCl), gained attention as important oxidative mediators in cardiac damage and dysfunction. As cardiomyocytes generate low-density lipoprotein (LDL)-like particles, we aimed to identify the footprints of proatherogen...