The Balance of MU-Opioid, Dopamine D2 and Adenosine A2A Heteroreceptor Complexes in the Ventral Striatal-Pallidal GABA Antireward Neurons May Have a Significant Role in Morphine and Cocaine Use Disorders

• Main Authors: Dasiel O. Borroto-Escuela (Author), Karolina Wydra (Author), Ramon Fores-Pons (Author), Lakshmi Vasudevan (Author), Wilber Romero-Fernandez (Author), Małgorzata Frankowska (Author), Luca Ferraro (Author), Sarah Beggiato (Author), Minerva Crespo-Ramirez (Author), Alicia Rivera (Author), Luisa L. Rocha (Author), Miguel Perez de la Mora (Author), Christophe Stove (Author), Małgorzata Filip (Author), Kjell Fuxe (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The widespread distribution of heteroreceptor complexes with allosteric receptor-receptor interactions in the CNS represents a novel integrative molecular mechanism in the plasma membrane of neurons and glial cells. It was proposed that they form the molecular basis for learning and short-and long-t...