The Balance of MU-Opioid, Dopamine D2 and Adenosine A2A Heteroreceptor Complexes in the Ventral Striatal-Pallidal GABA Antireward Neurons May Have a Significant Role in Morphine and Cocaine Use Disorders

• Egile Nagusiak: Dasiel O. Borroto-Escuela (Egilea), Karolina Wydra (Egilea), Ramon Fores-Pons (Egilea), Lakshmi Vasudevan (Egilea), Wilber Romero-Fernandez (Egilea), Małgorzata Frankowska (Egilea), Luca Ferraro (Egilea), Sarah Beggiato (Egilea), Minerva Crespo-Ramirez (Egilea), Alicia Rivera (Egilea), Luisa L. Rocha (Egilea), Miguel Perez de la Mora (Egilea), Christophe Stove (Egilea), Małgorzata Filip (Egilea), Kjell Fuxe (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The widespread distribution of heteroreceptor complexes with allosteric receptor-receptor interactions in the CNS represents a novel integrative molecular mechanism in the plasma membrane of neurons and glial cells. It was proposed that they form the molecular basis for learning and short-and long-t...