A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity

• Main Authors: Ali H. Abbas (Author), Ammar A. Razzak Mahmood (Author), Lubna H. Tahtamouni (Author), Zainab A. Al-Mazaydeh (Author), Majdoleen S. Rammaha (Author), Fatima Alsoubani (Author), Rheda I. Al-bayati (Author)
• Format: Book
• Published: Pensoft Publishers, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thirteen new derivatives of picolinic acid (4-7) were designed and synthesized from the starting parent molecule, picolinic acid. The new compounds were characterized by ATR-FTIR, 1HNMR, and CHNS analysis. A molecular docking study was performed to evaluate the binding affinity of the synthesized co...