Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells

• Main Authors: Yuzo Sato (Author), Shiori Matsuda (Author), Ami Maruyama (Author), Joji Nakayama (Author), Tomoyuki Miyashita (Author), Hibiki Udagawa (Author), Shigeki Umemura (Author), Kazuyoshi Yanagihara (Author), Atsushi Ochiai (Author), Masaru Tomita (Author), Tomoyoshi Soga (Author), Katsuya Tsuchihara (Author), Hideki Makinoshima (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antifolates are a class of drugs effective for treating malignant pleural mesothelioma (MPM). The majority of antifolates inhibit enzymes involved in purine and pyrimidine synthesis such as dihydrofolate reductase (DHFR), thymidylate synthase (TYMS), and glycinamide ribonucleotide formyltransferase...