Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

• Autores principales: Sabrina Reinehr (Autor), Sara C. Gomes (Autor), Caroline J. Gassel (Autor), M. Ali Asaad (Autor), Gesa Stute (Autor), Marc Schargus (Autor), H. Burkhard Dick (Autor), Stephanie C. Joachim (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

In glaucoma, studies revealed an involvement of the complement system. In an experimental autoimmune glaucoma model, immunization with an optic nerve homogenate antigen (ONA) led to retinal ganglion cell (RGC) loss, while intraocular pressure (IOP) remained unchanged. Here, we investigated the thera...