Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy

• Main Authors: Vedran Vasic (Author), Can Buldun (Author), Manfred Ritz (Author), Steffen Dickopf (Author), Guy J. Georges (Author), Christian Spick (Author), Alessa Peuker (Author), Thomas Meier (Author), Klaus Mayer (Author), Ulrich Brinkmann (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTAntibody-cytokine fusions targeted against tumor-associated antigens (TAAs) are promising cancer immunotherapy agents, with many such molecules currently undergoing clinical trials. However, due to the limited number of tumor-specific targets, on-target off-tumor effects can lead to systemic...