IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages

• Main Authors: Iris Aparici-Herraiz (Author), Guillem Sánchez-Sánchez (Author), Carlos Batlle (Author), Pere Rehues (Author), Martí López-Serrat (Author), Lorena Valverde-Estrella (Author), Jorge Lloberas (Author), Antonio Celada (Author)
• Format: Book
• Published: Karger Publishers, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melanoma differentiation-associated protein 5 (MDA5) induces type I interferons (IFNs) after the recognition of viral RNA. In addition, gain-of-function mutations in the interferon induced with helicase C domain 1 (IFIH1) gene, which encodes MDA5, lead to type I interferonopathies. Here, we show tha...