IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages
Melanoma differentiation-associated protein 5 (MDA5) induces type I interferons (IFNs) after the recognition of viral RNA. In addition, gain-of-function mutations in the interferon induced with helicase C domain 1 (IFIH1) gene, which encodes MDA5, lead to type I interferonopathies. Here, we show tha...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
Karger Publishers,
2022-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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