Structure-Based Optimization of 1,2,4-Triazole-3-Thione Derivatives: Improving Inhibition of NDM-/VIM-Type Metallo-β-Lactamases and Synergistic Activity on Resistant Bacteria

Structure-Based Optimization of 1,2,4-Triazole-3-Thione Derivatives: Improving Inhibition of NDM-/VIM-Type Metallo-β-Lactamases and Synergistic Activity on Resistant Bacteria

The worldwide emergence and dissemination of Gram-negative bacteria expressing metallo-β-lactamases (MBLs) menace the efficacy of all β-lactam antibiotics, including carbapenems, a last-line treatment usually restricted to severe pneumonia and urinary tract infections. Nonetheless, no MBL inhibitor...

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Main Authors: Matteo Bersani (Author), Mariacristina Failla (Author), Filippo Vascon (Author), Eleonora Gianquinto (Author), Laura Bertarini (Author), Massimo Baroni (Author), Gabriele Cruciani (Author), Federica Verdirosa (Author), Filomena Sannio (Author), Jean-Denis Docquier (Author), Laura Cendron (Author), Francesca Spyrakis (Author), Loretta Lazzarato (Author), Donatella Tondi (Author)
Format: Book
Published: MDPI AG, 2023-12-01T00:00:00Z.
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