Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides, and Their Effect on the 5α-Reductase Isoform 2, the Androgen Receptor, and Androgen-Dependent Glands

• Główni autorzy: Juan C. Lopez-Lezama (Autor), Marisa Cabeza (Autor), Yvonne Heuze (Autor), Araceli Sánchez (Autor), José L. Rojas (Autor), Norma A. Valencia-Islas (Autor)
• Format: Książka
• Wydane: Tabriz University of Medical Sciences, 2022-07-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Background: Benign Prostatic Hyperplasia (BPH), and Prostate Cancer (PCa) are androgen-dependent diseases. PPCa is associated with excessive signalling of the androgen receptor (AR) due to the binding of 5α-dihydrotestosterone (5α-DHT) and testosterone (T). BPH is related to high levels of 5α-DHT, b...