Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides, and Their Effect on the 5α-Reductase Isoform 2, the Androgen Receptor, and Androgen-Dependent Glands

Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides, and Their Effect on the 5α-Reductase Isoform 2, the Androgen Receptor, and Androgen-Dependent Glands

Background: Benign Prostatic Hyperplasia (BPH), and Prostate Cancer (PCa) are androgen-dependent diseases. PPCa is associated with excessive signalling of the androgen receptor (AR) due to the binding of 5α-dihydrotestosterone (5α-DHT) and testosterone (T). BPH is related to high levels of 5α-DHT, b...

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Main Authors: Juan C. Lopez-Lezama (Author), Marisa Cabeza (Author), Yvonne Heuze (Author), Araceli Sánchez (Author), José L. Rojas (Author), Norma A. Valencia-Islas (Author)
Format: Book
Published: Tabriz University of Medical Sciences, 2022-07-01T00:00:00Z.
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3rd Floor Main Library

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