Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain

• Main Authors: Jianrong Liu (Author), Barbara Wenzel (Author), Sladjana Dukic-Stefanovic (Author), Rodrigo Teodoro (Author), Friedrich-Alexander Ludwig (Author), Winnie Deuther-Conrad (Author), Susann Schröder (Author), Jean-Michel Chezal (Author), Emmanuel Moreau (Author), Peter Brust (Author), Aurélie Maisonial-Besset (Author)
• Format: Book
• Published: MDPI AG, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phosphodiesterases (PDEs) are enzymes that play a major role in cell signalling by hydrolysing the secondary messengers cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP) throughout the body and brain. Altered cyclic nucleotide-mediated signalling has been associated...