Nimesulide linked acyl thioureas potent carbonic anhydrase I, II and α-glucosidase inhibitors: Design, synthesis and molecular docking studies

• Main Authors: Atteeque Ahmed (Author), Imran Shafique (Author), Aamer Saeed (Author), Ghulam Shabir (Author), Arslan Saleem (Author), Parham Taslimi (Author), Tugba Taskin Tok (Author), Mahinur Kirici (Author), Eda Mehtap Üç (Author), Muhammad Zaffar Hashmi (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Molecular hybridization has emerged as an interesting strategy to improve the effectiveness and the scope of well-known drugs. Nimesulide has been used as non-steroidal anti-inflammatory (NSAID) drug for decades and marketed as NIMS™. Nimesulide (3) possesses a nitro group which shows toxic behavior...