Analyzing Alkyl Bromide Genotoxic Impurities in Febuxostat Based on Static Headspace Sampling and GC-ECD

• Príomhchruthaitheoirí: Alexandros Kavrentzos (Údar), Elli Vastardi (Údar), Evangelos Karavas (Údar), Paraskevas D. Tzanavaras (Údar), Constantinos K. Zacharis (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2024-03-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Herein, a sensitive and selective gas chromatography-electron capture detector (GC-ECD) method was developed and validated for the quantification of trace levels of five bromo-containing genotoxic impurities in Febuxostat active pharmaceutical ingredient (API) after headspace sampling (HS). Multivar...