SDF-1/CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes

• Main Authors: Ning-Bo Hao (Author), Chang-Zhu Li (Author), Mu-Han Lü (Author), Bo Tang (Author), Su-Min Wang (Author), Yu-Yun Wu (Author), Guang-Ping Liang (Author), Shi-Ming Yang (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MSCs have become a popular target for developing end-stage liver therapies. In this study, two models of bone marrow chimeric mice were used to construct the liver failure models. Then it was found that MSCs can transdifferentiate into hepatocyte-like cells and these hepatocyte-like cells can signif...