Development and Validation of an Improved HPLC-MS/MS Method for Quantifying Total and Unbound Lenalidomide in Human Plasma

• Main Authors: Suhyun Lee (Author), Seungwon Yang (Author), Wang-Seob Shim (Author), Eunseo Song (Author), Seunghoon Han (Author), Sung-Soo Park (Author), Suein Choi (Author), Sung Hwan Joo (Author), Seok Jun Park (Author), Beomjin Shin (Author), Donghyun Kim (Author), Hyeonsu Kim (Author), Yujung Jung (Author), Kyung-Tae Lee (Author), Eun Kyoung Chung (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Objectives: This study aimed to develop a fully validated HPLC-MS/MS method for quantifying total and unbound lenalidomide concentrations in human plasma. Methods: Unbound concentrations were measured using plasma ultrafiltrate prepared with Amicon^® Centrifugal Filt...