Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish

• المؤلفون الرئيسيون: Evisa Gjini (مؤلف), Chang-Bin Jing (مؤلف), Ashley T. Nguyen (مؤلف), Deepak Reyon (مؤلف), Emma Gans (مؤلف), Michiel Kesarsing (مؤلف), Joshua Peterson (مؤلف), Olga Pozdnyakova (مؤلف), Scott J. Rodig (مؤلف), Marc R. Mansour (مؤلف), Keith Joung (مؤلف), A. Thomas Look (مؤلف)
• التنسيق: كتاب
• منشور في: The Company of Biologists, 2019-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Somatic loss-of-function mutations of the additional sex combs-like transcriptional regulator 1 (ASXL1) gene are common genetic abnormalities in human myeloid malignancies and induce clonal expansion of mutated hematopoietic stem cells (HSCs). To understand how ASXL1 disruption leads to myeloid cell...