Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish

• Main Authors: Evisa Gjini (Author), Chang-Bin Jing (Author), Ashley T. Nguyen (Author), Deepak Reyon (Author), Emma Gans (Author), Michiel Kesarsing (Author), Joshua Peterson (Author), Olga Pozdnyakova (Author), Scott J. Rodig (Author), Marc R. Mansour (Author), Keith Joung (Author), A. Thomas Look (Author)
• Format: Book
• Published: The Company of Biologists, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Somatic loss-of-function mutations of the additional sex combs-like transcriptional regulator 1 (ASXL1) gene are common genetic abnormalities in human myeloid malignancies and induce clonal expansion of mutated hematopoietic stem cells (HSCs). To understand how ASXL1 disruption leads to myeloid cell...