Antioxidant Response in Human X-Linked Adrenoleukodystrophy Fibroblasts

• Main Authors: Sara Petrillo (Author), Jessica D'Amico (Author), Francesco Nicita (Author), Caterina Torda (Author), Gessica Vasco (Author), Enrico S. Bertini (Author), Marco Cappa (Author), Fiorella Piemonte (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Redox imbalance, mitochondrial dysfunction, and inflammation play a major role in the pathophysiology of X-linked adrenoleukodystrophy (X-ALD), an inherited neurodegenerative disease caused by mutations in the ABCD1 gene, encoding the protein responsible for peroxisomal import and degradation of ver...