QSAR Studies, Molecular Docking, Molecular Dynamics, Synthesis, and Biological Evaluation of Novel Quinolinone-Based Thiosemicarbazones against <i>Mycobacterium tuberculosis</i>

• Main Authors: Jhesua Valencia (Author), Vivian Rubio (Author), Gloria Puerto (Author), Luisa Vasquez (Author), Anthony Bernal (Author), José R. Mora (Author), Sebastian A. Cuesta (Author), José Luis Paz (Author), Braulio Insuasty (Author), Rodrigo Abonia (Author), Jairo Quiroga (Author), Alberto Insuasty (Author), Andres Coneo (Author), Oscar Vidal (Author), Edgar Márquez (Author), Daniel Insuasty (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, a series of novel quinolinone-based thiosemicarbazones were designed in silico and their activities tested in vitro against <i>Mycobacterium tuberculosis</i> (<i>M. tuberculosis</i>). Quantitative structure-activity relationship (QSAR) studies were performed us...