Empagliflozin activates Wnt/β-catenin to stimulate FUNDC1-dependent mitochondrial quality surveillance against type-3 cardiorenal syndrome

• Main Authors: Chen Cai (Author), Feng Wu (Author), Bingjie Zhuang (Author), Qing Ou (Author), Xiaojie Peng (Author), Nengxian Shi (Author), Lan Peng (Author), Ziying Li (Author), Jin Wang (Author), Shumin Cai (Author), Ying Tan (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Cardiorenal syndrome type-3 (CRS-3) is an abrupt worsening of cardiac function secondary to acute kidney injury. Mitochondrial dysfunction is a key pathological mechanism of CRS-3, and empagliflozin can improve mitochondrial biology by promoting mitophagy. Here, we assessed the effects o...