Sickle Cell Disease-Genetics, Pathophysiology, Clinical Presentation and Treatment

• Main Authors: Baba P. D. Inusa (Author), Lewis L. Hsu (Author), Neeraj Kohli (Author), Anissa Patel (Author), Kilali Ominu-Evbota (Author), Kofi A. Anie (Author), Wale Atoyebi (Author)
• Format: Book
• Published: MDPI AG, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in the β-globin chain. Phenotypic variation in the clinical presentation and disease outcome is a characteristic...