Chronic exposure to cigarette smoke extract increases nicotine withdrawal symptoms in adult and adolescent male rats

• Main Authors: Daisy D. Reynaga (Author), Michelle Cano (Author), James D. Belluzzi (Author), Frances M. Leslie (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The aim of the current study was to determine whether non-nicotine constituents of cigarette smoke contribute to nicotine dependence in adolescent and adult male Sprague Dawley rats. For 10 days animals were given three times daily intravenous injections of nicotine (1.5 mg/kg/day) or cigarette smok...