Comparison of Steroid Hormone Hydroxylations by and Docking to Human Cytochromes P450 3A4 and 3A5

• 主要な著者: Toshiro Niwa (著者), Kanae Narita (著者), Ayaka Okamoto (著者), Norie Murayama (著者), Hiroshi Yamazaki (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Purpose: Hydroxylation activity at the 6β-position of steroid hormones (testosterone, progesterone, and cortisol) by human cytochromes P450 (P450 or CYP) 3A4 and CYP3A5 and their molecular docking energy values were compared to understand the catalytic properties of the major forms of human CYP3A, n...