Aptamer-mediated transcriptional gene silencing of Foxp3 inhibits regulatory T cells and potentiates antitumor response

• Main Authors: Andrea J. Manrique-Rincón (Author), Luciana P. Ruas (Author), Carolinne T. Fogagnolo (Author), Randall J. Brenneman (Author), Alexey Berezhnoy (Author), Bianca Castelucci (Author), Sílvio R. Consonni (Author), Eli Gilboa (Author), Marcio C. Bajgelman (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The inhibition of immunosuppressive mechanisms may switch the balance between tolerance and surveillance, leading to an increase in antitumor activity. Regulatory T cells play an important role in the control of immunosuppression, exhibiting the unique property of inhibiting T cell proliferation. Th...