Cardiac DPP-4 inhibition by saxagliptin ameliorates isoproterenol-induced myocardial remodeling and cardiac diastolic dysfunction in rats

• Main Authors: Junichi Ikeda (Author), Naoya Kimoto (Author), Tetsuya Kitayama (Author), Shunji Kunori (Author)
• פורמט: ספר
• יצא לאור: Elsevier, 2016-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Saxagliptin, a potent and selective DPP-4 inhibitor, is characterized by its slow dissociation from DPP-4 and its long half-life and is expected to have a potent tissue membrane-bound DPP-4-inhibitory effect in various tissues. In the present study, we examined the effects of saxagliptin on in situ...