The Crosstalk between GPR81/IGFBP6 Promotes Breast Cancer Progression by Modulating Lactate Metabolism and Oxidative Stress

• Main Authors: Lucia Longhitano (Author), Stefano Forte (Author), Laura Orlando (Author), Stephanie Grasso (Author), Alessandro Barbato (Author), Nunzio Vicario (Author), Rosalba Parenti (Author), Paolo Fontana (Author), Angela M. Amorini (Author), Giuseppe Lazzarino (Author), Giovanni Li Volti (Author), Michelino Di Rosa (Author), Arcangelo Liso (Author), Barbara Tavazzi (Author), Giacomo Lazzarino (Author), Daniele Tibullo (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Breast cancer is the most frequent tumor and the leading cause of cancer deaths in women. In recent years, lactate metabolism and, in particular, its receptor GPR81 have been shown to play a vital role in cancer biology. GPR81 is upregulated in breast cancer and promotes tumor growth by tumor cell-d...