New Applications of JAK/STAT Inhibitors in Pediatrics: Current Use of Ruxolitinib

• Main Authors: Annalisa Marcuzzi (Author), Erika Rimondi (Author), Elisabetta Melloni (Author), Arianna Gonelli (Author), Antonio Giacomo Grasso (Author), Egidio Barbi (Author), Natalia Maximova (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Janus kinases (JAK) are a family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) that transduce cytokine-mediated signals through the JAK-STAT metabolic pathway. These kinases act by regulating the transcription of specific genes capable of inducing biological responses in several immune cell subse...