Gestational Age-Dependent Increase of Survival Motor Neuron Protein in Umbilical Cord-Derived Mesenchymal Stem Cells

• Main Authors: Sota Iwatani (Author), Nur Imma Fatimah Harahap (Author), Dian Kesumapramudya Nurputra (Author), Shinya Tairaku (Author), Akemi Shono (Author), Daisuke Kurokawa (Author), Keiji Yamana (Author), Khin Kyae Mon Thwin (Author), Makiko Yoshida (Author), Masami Mizobuchi (Author), Tsubasa Koda (Author), Kazumichi Fujioka (Author), Mariko Taniguchi-Ikeda (Author), Hideto Yamada (Author), Ichiro Morioka (Author), Kazumoto Iijima (Author), Hisahide Nishio (Author), Noriyuki Nishimura (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundSpinal muscular atrophy (SMA) is the most common genetic neurological disease leading to infant death. It is caused by loss of survival motor neuron (SMN) 1 gene and subsequent reduction of SMN protein in motor neurons. Because SMN is ubiquitously expressed and functionally linked to gener...