Risk of Myopathy in Patients in Therapy with Statins: Identification of Biological Markers in a Pilot Study

• Main Authors: Giulia M. Camerino (Author), Olimpia Musumeci (Author), Elena Conte (Author), Kejla Musaraj (Author), Adriano Fonzino (Author), Emanuele Barca (Author), Marco Marino (Author), Carmelo Rodolico (Author), Domenico Tricarico (Author), Claudia Camerino (Author), Maria R. Carratù (Author), Jean-François Desaphy (Author), Annamaria De Luca (Author), Antonio Toscano (Author), Sabata Pierno (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Statin therapy may induce skeletal muscle damage ranging from myalgia to severe rhabdomyolysis. Our previous preclinical studies showed that statin treatment in rats involves the reduction of skeletal muscle ClC-1 chloride channel expression and related chloride conductance (gCl). An increase of the...