Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

• Main Authors: Ashok Aspatwar (Author), Holger M. Becker (Author), Nanda Kumar Parvathaneni (Author), Milka Hammaren (Author), Aleksandra Svorjova (Author), Harlan Barker (Author), Claudiu T. Supuran (Author), Ludwig Dubois (Author), Philippe Lambin (Author), Mataleena Parikka (Author), Seppo Parkkila (Author), Jean-Yves Winum (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carbonic anhydrase (CA) IX is a hypoxia inducible enzyme that is highly expressed in solid tumours. Therefore, it has been considered as an anticancer target using specific chemical inhibitors. The nitroimidazoles DTP338 and DTP348 have been shown to inhibit CA IX in nanomolar range in vitro and red...