Negatively charged phospholipids doped liposome delivery system for mRNA with high transfection efficiency and low cytotoxicity

• Main Authors: Lin Wang (Author), Huanchun Xing (Author), Shuai Guo (Author), Wenbin Cao (Author), Zinan Zhang (Author), Lijuan Huang (Author), Sui Xin (Author), Yuan Luo (Author), Yongan Wang (Author), Jun Yang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractMessenger RNA (mRNA) has become one of the most potential drugs in recent years. However, efficient and safe delivery of fragile and easily degradable mRNA is a major challenge. Appropriate delivery system (DS) determines the final effect of mRNA. Cationic lipids play a crucial and decisive...