Effects of IKur blocker MK-0448 on human right atrial action potentials from pateints in sinus rhythm and in permanent atrial fibrillation.

• Main Authors: Simone eLoose (Author), Judith eMueller (Author), Erich eWettwer (Author), Michael eKnaut (Author), John eFord (Author), James eMilnes (Author), Ursula eRavens (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Selective blockers of the Kv1.5 channel have been developed for the treatment of atrial fibrillation (AF), but little is known how these atrial-selective drugs affect human action potentials (APs). Therefore we have investigated the Kv1.5 blocker MK-0448 (N-{6-[(1S)-1-(4-fluorophenyl)-2,2-di(pyridin...