Stereoselective inhibition of the hERG1 potassium channel

• Main Authors: Liliana eSintra Grilo (Author), Pierre-Alain eCarrupt (Author), Hugues eAbriel (Author)
• Format: Book
• Published: Frontiers Media S.A., 2010-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A growing number of drugs have been shown to prolong cardiac repolarization, predisposing individuals to life-threatening ventricular arrhythmias known as Torsades de Pointes. Most of these drugs are known to interfere with the human ether à-gogo related gene 1 (hERG1) channel, whose curren...