Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety

• Main Authors: Takuji Shoda (Author), Nobumichi Ohoka (Author), Genichiro Tsuji (Author), Takuma Fujisato (Author), Hideshi Inoue (Author), Yosuke Demizu (Author), Mikihiko Naito (Author), Masaaki Kurihara (Author)
• Format: Book
• Published: MDPI AG, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeted protein degradation using small chimeric molecules, such as proteolysis-targeting chimeras (PROTACs) and specific and nongenetic inhibitors of apoptosis protein [IAP]-dependent protein erasers (SNIPERs), is a promising technology in drug discovery. We recently developed a novel class of chi...